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We benchmarked native WebStream pipeThrough at 630 MB/s for 1KB chunks. Node.js pipeline() with the same passthrough transform: ~7,900 MB/s. That is a 12x gap, and the difference is almost entirely Promise and object allocation overhead."
It’s also worth noting that even if alternatives superior to agar were found, scientists are reluctant to abandon established protocols (even when microbiologists do use other jellies, they often still add agar to the mix, for example, to increase the gel strength of the solid media). As agar has been the standard gelling agent in microbiology for around 150 years, an enormous infrastructure of standardized methods, reference values, and quality control procedures has emerged around its specific properties. Switching to a different medium (even a superior one) means results may not be directly comparable to decades of published literature or to other laboratories’ findings.